 |
 |
醫(yī)學(xué)論文范文:銀杏葉提取物治療抗抑郁劑所致不良反應(yīng)對(duì)照研究
【摘要】 目的 探討銀杏葉提取物緩解抗抑郁劑治療初期所致不良反應(yīng)的臨床效果。 方法 將100例抑郁癥患者隨機(jī)分為兩組各50例，研究組給予抗抑郁劑聯(lián)合銀杏葉提取物注射液治療，對(duì)照組單用抗抑郁劑治療，觀察6 w。于治療前和治療第1 w、2 w、3 w、4 w、5 w、6 w末采用漢密頓抑郁量表、漢密頓焦慮量表及抑郁自評(píng)量表、焦慮自評(píng)量表評(píng)定臨床療效，并記錄兩組不良反應(yīng)。 結(jié)果 兩組治療后各周末漢密頓抑郁量表、漢密頓焦慮量表及抑郁自評(píng)量表、焦慮自評(píng)量表評(píng)分均較治療前顯著下降（P＜0.01)，并隨著治療時(shí)間的延續(xù)均呈持續(xù)性下降；治療各周末研究組均較對(duì)照組下降顯著（P＜0.05或0.01)。研究組治療第1 w、2 w、3 w末不良反應(yīng)發(fā)生率顯著低于對(duì)照組（P＜0.05或0.01)，4 w末起兩組無(wú)顯著性差異（P＞0.05)。 結(jié)論 銀杏葉提取物注射液能有效緩解抗抑郁劑治療初期所致的不良反應(yīng)，顯著提高治療依從性。
【關(guān)鍵詞】 抑郁癥；銀杏葉提取物；抗抑郁劑；不良反應(yīng)；漢密頓抑郁量表；漢密頓焦慮量表；抑郁自評(píng)量表；焦慮自評(píng)量表
A control study of Ginaton relieving adverse reactions caused by antidepressant at initial stage
Wang Xiuhong,Hu Wei
(Psychological Department, Nandi Hospital of Bengang,Benxi 117000,Liaoning,China)
【Abstract】 Objective To explore the clinical efficacy of Ginaton relieving adverse reactions caused by antidepressant at initial stage.Methods One hundred hospitalized depression patients were randomly assigned to research group(n=50) treated with antidepressant plus Ginaton injection and control group(n=50) with single antidepressant for 6 weeks. Clinical efficacies were assessed with the Hamilton Depression Scale(HAMD), the Hamilton Anxiety Scale(HAMA), the Selfrating Depression Sacle(SDS) and the Selfrating Anxiety Scale(SAS) before treatment and at the ends of the 1st,2nd,3rd,4th,5th and 6th week treatment, and adverse reactions recorded. Results After treatment, scores of the HAMD,HAMA,SDS and SAS of both groups all lowered more significantly compared with pretreatment(P<0.01) and did continously along with time of therapy lasting; those lowered more significantly at each weekend in the research than in the control group(P<0.05 or 0.01). incidences of adverse reactions were significantly lower in the research than in the control group at the ends of the first three week(P<0.05 or 0.01),there were no significant differences between the 2 groups since the end of the 4th week(P>0.05).Conclusion Ginaton injection can effectively relieves adverse reactions caused by antidepressant at initial stage, improve drug’s compliance and augment drug’s efficacy醫(yī).學(xué)全.在.線網(wǎng)站m.f1411.cn.
【Keywords】 Depression; Ginaton; antidepressant;adverse reactions;HAMD;HAMA;SDS;SAS
5羥色胺再攝取抑制劑（SSRIs)抗抑郁劑類治療抑郁癥臨床效果顯著，但服藥后常在治療初期出現(xiàn)諸多的不良反應(yīng)，影響了患者服藥物的依從性，進(jìn)而影響療效。為了減輕或緩解SSRIs類藥物治療初期出現(xiàn)的不良反應(yīng)，改善患者軀體和情緒癥狀，作者對(duì)應(yīng)用SSRIS類藥物治療的抑郁癥患者聯(lián)合靜脈滴注銀杏葉提取物進(jìn)行了相關(guān)對(duì)照研究，現(xiàn)將結(jié)果報(bào)告如下。
1 對(duì)象與方法
1.1 對(duì)象 選取2007年5月～2007年12月在我院心理科住院的抑郁癥患者為研究對(duì)象。入組標(biāo)準(zhǔn)：（1)符合《中國(guó)精神障礙分類與診斷標(biāo)準(zhǔn)》第3版（CCMD3)［1］抑郁發(fā)作診斷標(biāo)準(zhǔn)。（2)漢密頓抑郁量表（HAMD)≥20分，漢密頓焦慮量表（HAMA)≥14分，抑郁自評(píng)量表（SDS)＞53分，焦慮自評(píng)量表（SAS)＞50分。（3)文化程度在初中以上，年齡18 a～60 a。（4)首次服SSRIs類藥物。（5)排除嚴(yán)重軀體疾病、實(shí)驗(yàn)室檢查嚴(yán)重異常者、嚴(yán)重自殺傾向者、藥物或酒精過(guò)敏、妊娠或哺乳婦女及雙相情感障礙快速循環(huán)相等精神障礙者。共入組100例，隨機(jī)分為兩組各50例。研究組男21例，女29例，平均年齡（31±7) a，平均病程（3.2±0.4) a。對(duì)照組男24例，女26例，平均年齡（30±8) a，平均病程（3.1±0.6) a。
1.2 方法
